An Escherichia coli Nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic.

@article{Adediran2014AnEC,
  title={An Escherichia coli Nissle 1917 missense mutant colonizes the streptomycin-treated mouse intestine better than the wild type but is not a better probiotic.},
  author={Jimmy Adediran and Mary P. Leatham-Jensen and Matthew E Mokszycki and Jakob Frimodt-M\oller and Karen Angeliki Krogfelt and Krystyna M. Kazmierczak and Linda J Kenney and Tyrrell Conway and Paul S. Cohen},
  journal={Infection and immunity},
  year={2014},
  volume={82 2},
  pages={670-82}
}
Previously we reported that the streptomycin-treated mouse intestine selected for two different Escherichia coli MG1655 mutants with improved colonizing ability: nonmotile E. coli MG1655 flhDC deletion mutants that grew 15% faster in vitro in mouse cecal mucus and motile E. coli MG1655 envZ missense mutants that grew slower in vitro in mouse cecal mucus yet were able to cocolonize with the faster-growing flhDC mutants. The E. coli MG1655 envZ gene encodes a histidine kinase that is a member of… CONTINUE READING

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Regulation of porin gene expression by the two-component regulatory system EnvZ/OmpR, p 1–24

  • D Walthers, A Go, LJ. Kenney
  • 2004
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