An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link

@article{Kelly2009AnEV,
  title={An Epstein-Barr Virus Anti-Apoptotic Protein Constitutively Expressed in Transformed Cells and Implicated in Burkitt Lymphomagenesis: The Wp/BHRF1 Link},
  author={Gemma L. Kelly and Heather M. Long and Julianna Stylianou and Wendy A. Thomas and Alison M. Leese and Andrew I Bell and Georg W. Bornkamm and Josef Mautner and Alan B. Rickinson and Martin Rowe},
  journal={PLoS Pathogens},
  year={2009},
  volume={5},
  pages={1397 - 1402}
}
Two factors contribute to Burkitt lymphoma (BL) pathogenesis, a chromosomal translocation leading to c-myc oncogene deregulation and infection with Epstein-Barr virus (EBV). Although the virus has B cell growth-transforming ability, this may not relate to its role in BL since many of the transforming proteins are not expressed in the tumor. Mounting evidence supports an alternative role, whereby EBV counteracts the high apoptotic sensitivity inherent to the c-myc-driven growth program. In that… CONTINUE READING
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