An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance

@article{Byers2012AnET,
  title={An Epithelial–Mesenchymal Transition Gene Signature Predicts Resistance to EGFR and PI3K Inhibitors and Identifies Axl as a Therapeutic Target for Overcoming EGFR Inhibitor Resistance},
  author={L. Byers and Lixia Diao and J. Wang and P. Saintigny and L. Girard and M. Peyton and L. Shen and Y. Fan and U. Giri and Praveen K. Tumula and M. Nilsson and J. Gudikote and H. Tran and R. Cardnell and D. Bearss and S. Warner and Jason M. Foulks and Steven B. Kanner and V. Gandhi and N. Krett and S. Rosen and E. Kim and R. Herbst and G. Blumenschein and J. J. Lee and S. Lippman and K. K. Ang and G. Mills and W. Hong and J. Weinstein and I. Wistuba and K. Coombes and J. Minna and J. Heymach},
  journal={Clinical Cancer Research},
  year={2012},
  volume={19},
  pages={279 - 290}
}
  • L. Byers, Lixia Diao, +31 authors J. Heymach
  • Published 2012
  • Medicine, Biology
  • Clinical Cancer Research
  • Purpose: Epithelial–mesenchymal transition (EMT) has been associated with metastatic spread and EGF receptor (EGFR) inhibitor resistance. We developed and validated a robust 76-gene EMT signature using gene expression profiles from four platforms using non–small cell lung carcinoma (NSCLC) cell lines and patients treated in the Biomarker-Integrated Approaches of Targeted Therapy for Lung Cancer Elimination (BATTLE) study. Experimental Design: We conducted an integrated gene expression… CONTINUE READING
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