An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential

@inproceedings{Casadevall2014AnEP,
  title={An Epistemological Perspective on the Value of Gain-of-Function Experiments Involving Pathogens with Pandemic Potential},
  author={Arturo Casadevall and Don A. Howard and Michael J Imperiale},
  booktitle={mBio},
  year={2014}
}
In recent years, scientists have engaged in a vigorous debate regarding the value of so-called gain-of-function (GOF) experiments involving highly pathogenic avian influenza virus (HPAIV) and other pathogens with pandemic potential (PPP). Of particular concern have been experiments whereby something is done to PPP, such as HPAIV, and the pathogen acquires a new property, or GOF, that makes the microbe more dangerous, such as mammalian transmissibility, increased virulence, and/or the ability to… CONTINUE READING
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