An Epistemological Inquiry into the Endocrine Disruptor Thesis

@article{Krimsky2001AnEI,
  title={An Epistemological Inquiry into the Endocrine Disruptor Thesis},
  author={Sheldon Krimsky},
  journal={Annals of the New York Academy of Sciences},
  year={2001},
  volume={948}
}
  • S. Krimsky
  • Published 1 December 2001
  • Psychology, Medicine
  • Annals of the New York Academy of Sciences
Abstract: For about a decade the term endocrine disruptor has become synonymous with a new research initiative that has been investigating the effects of hormonally active xenobiotics on biological systems. The scientific thesis behind the new research initiative is discussed and it is argued that there is a need for more emphasis on theory development and conceptual clarification that will give coherence to a field experiencing a rapid growth of empirical studies. Reflections on scientific… 
Chapter 67 – Endocrine disruptors
TLDR
This chapter defines important terms, key concepts and processes associated with endocrine disruption, which encompasses a wide range of mechanisms of action which can ultimately result in adverse effects on individual animals or susceptible animal populations.
The politics of plastics: the making and unmaking of bisphenol a "safety".
  • Sarah A. Vogel
  • Business, Medicine
    American journal of public health
  • 2009
TLDR
New research on very-low-dose exposure to BPA suggests an association with adverse health effects, including breast and prostate cancer, obesity, neurobehavioral problems, and reproductive abnormalities, which challenge the long-standing scientific and legal presumption of BPA's safety.
Reproductive Toxicity and Endocrine Disruption
TLDR
The information presented in this chapter was intended to familiarize the reader with terminology and concepts pertinent to reproductive toxicity and endocrine disruption, as well as to provide an overview of reproductive development, anatomy and physiology and aspects of these processes susceptible to toxic insult by naturally occurring and synthetic xenobiotics.
Multi-generation health risks of persistent organic pollution in the far north: use of the precautionary approach in the Stockholm Convention
Abstract Precautionary regulation of persistent, toxic substances is controversial because of continued and irresolvable uncertainties in ecotoxicology. This is especially an issue for people who eat
Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents
TLDR
This chapter describes the basic terminology with respect to reproduction, reproductive toxicity, and endocrine disruption, as well as what is currently understood about the potential adverse effects of chemical warfare agents, ionizing radiation, and hazardous industrial and agricultural wastes on human and animal reproductive function.
CHAPTER 14 – Reproductive toxicity and endocrine disruption
TLDR
Efforts are made to clarify the currently used terminology related to reproductive toxicity and endocrine disruption and to introduce the reader to normal reproductive anatomy and physiology, as well as important concepts associated with embryonic and fetal development.
CHAPTER 36 – Reproductive Toxicity and Endocrine Disruption of Potential Chemical Warfare Agents
Publisher Summary This chapter discusses what is currently known about the adverse effects of known chemical warfare agents (CWA) and selected environmental contaminants on male and female
The Influence of Scientific Claims on an Emerging Environmental Issue
The environmental movement relies on scientific claims to justify its calls for protectionist policies. These claims can be followed in the scientific literature using bibliometric methods such as
p,p′-DDE activates CatSper and compromises human sperm function at environmentally relevant concentrations
TLDR
A novel non-genomic p,p′-DDE mechanism specific to sperm was able to induce [Ca2+]i rise in human sperm through the opening of CatSper consequently compromising male fertility and may predispose human sperm to the action of some persistent endocrine disruptors.
Endocrine Disruption by the Consumption of Fish ( Tilapia oreochromis ) from Heavy Metals Polluted River Sites and its Reversal Using Zinc
TLDR
It is suggested that ingestion of fishes from heavily polluted sites by animals is capable of inducing low progesterone levels and prolactinaemia which can lead to infertility and the ingestion of a daily supplement in form of zinc can reverse this change.
...
1
2
3
...

References

SHOWING 1-10 OF 30 REFERENCES
Organization versus activation: the role of endocrine-disrupting contaminants (EDCs) during embryonic development in wildlife.
TLDR
The organizational model suggests that a small quantity of an EDC, administered during a specific period of embryonic development, can permanently modify the organization of the reproductive, immune, and nervous systems.
Panel Cautiously Confirms Low-Dose Effects
TLDR
An expert panel concluded that estrogenic chemicals can cause biological effects in lab animals at levels below those normally found to be safe--which runs counter to the conventional wisdom in toxicology.
Exposure to hazardous substances and male reproductive health: a research framework.
TLDR
The evidence and methodologies that have contributed to the current understanding of environmental effects on male reproductive health and fertility are reviewed, and the methodologic issues which confront investigators in this area are discussed.
Prediction and assessment of the effects of mixtures of four xenoestrogens.
TLDR
Assessment of two-, three- and four-component mixtures of o,p'-DDT, genistein, 4-nonylphenol, and 4- n-octylphenol with well-documented estrogenic activity shows good agreement between predicted and observed mixture effects in all cases.
Estrogens and development.
TLDR
Exposure of experimental animals or humans to the potent exogenous estrogen, diethylstilbestrol, results in persistent differentiation effects and the possibility of hormonally altered differentiation must be considered.
Plasma organochlorine levels and the risk of breast cancer.
TLDR
The hypothesis that exposure to DDT and PCBs increases the risk of breast cancer is rejected, as the data do not support the hypothesis.
Effect of DDT on Testes and Secondary Sex Characters of White Leghorn Cockerels
  • H. Burlington, V. F. Lindeman
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1950
TLDR
In this study on cockerels, some interesting effects were noted on the development of the testes and secondary sex characters and the amount of compound administered was gradually increased during the course of the experiment from an initial dose of 15 mg per kilo of body weight in the young birds to a maximum of 300 mg per Kilo near the terminal stages of the study.
Molecular structures of metabolites and analogues of diethylstilbestrol and their relationship to receptor binding and biological activity.
TLDR
Comparison of the observed conformations of I, II, III, DES, and estradiol suggests that it is the alpha-ring of I and II that minics the steroid A-ring in receptor binding, and that two of the four possible alpha- ring/A-ring matches are most conducive to eliciting hormone activity.
Dietary phytoestrogens.
TLDR
Dietary phytoestrogens play an important role in prevention of menopausal symptoms, osteoporosis, cancer, and heart disease and there may be great benefit in increased consumption of plant foods.
INTELLECTUAL IMPAIRMENT IN CHILDREN EXPOSED TO POLYCHLORINATED BIPHENYLS IN UTERO
A BSTRACT Background In utero exposure to polychlorinated biphenyls, a ubiquitous environmental contaminant, has been linked to adverse effects on neurologic and intellectual function in infants and
...
1
2
3
...