An Enzyme from Bacteria able to Destroy Penicillin

@article{Abraham1940AnEF,
  title={An Enzyme from Bacteria able to Destroy Penicillin},
  author={Edward P. Abraham and Ernst Boris Chain},
  journal={Nature},
  year={1940},
  volume={146},
  pages={837-837}
}
FLEMING1 noted that the growth of B. coli and a number of other bacteria belonging to the colityphoid group was not inhibited by penicillin. This observation has been confirmed. Further work has been done to find the cause of the resistance of these organisms to the action of penicillin. 

Topics from this paper

The thermostability of penicillinase.
SUMMARY: Extracellular penicillinase produced by the growth of five different strains of the genus Bacillus in casein hydrolysate is rapidly inactivated at 100°, but can be strikingly protectedExpand
A Thermostabile, Fungistatic Factor from Escherichia coli
WHEN cultivating Penicillium notatum Westl. and related fungi for the purpose of producing penicillin, it was soon noticed that the production of penicillin was inhibited by certain bacteria. It wasExpand
The Susceptibility of Penicillinase-producing Bacteria to Penicillin
TLDR
It appeared worth while to study a wide variety of such organisms to determine further the factors that influence their susceptibility to penicillin. Expand
On Penicillin Inactivators and Susceptibility of Micro-Organisms to Penicillin
TLDR
In the course of mass production of the antibiotic and its use in enormous amounts for parenteral treatment, two other accidental inactivations were observed. Expand
Chemistry and Biosynthesis of Penicillins and Cephalosporins
It has now been more than 50 years since Fleming’s legendary observations on the inhibition of bacterial growth by Penicillium notatum laid the foundations of modern antibiotic chemotherapy.
An evaluation of 12 methods for the demonstration of penicillinase.
Twelve methods for the demonstration of bacterial penicillinase production by strains of Haemophilus influenzae and Staphylococcus aureus are compared, and their suitability for routine clinicalExpand
Alexander Fleming: the spectrum of penicillin.
TLDR
The ability of staphylococci to produce this enzyme has been countered by the development of penicillinase-resistant agents and the addition of beta-lactamase inhibitors to antibiotics. Expand
EXTRACTION OF A HIGHLY POTENT PENICILLIN INACTIVATOR FROM PENICILLIN RESISTANT STAPHYLOCOCCI
A highly potent penicillin inactivator has been extracted from 7 strains of Staph. aureus (coagulase positive), all of which were naturally penicillin resistant. No such inhibitor was present inExpand
Formation of 6-Aminopenicillanic Acid by Alkaline Hydrolysis of Penicillins
TLDR
Two groups of enzymes hydrolyse penicillins (I) and penicillinase1, which opens the β-lactam ring to form the corresponding penicilloic acid (II). Expand
Beta-lactamase production in anaerobic bacteria
TLDR
The production, genetic determinant, ecological impact and the effects of β-lactamase on therapy is discussed and resistance to β- lactam drugs takes place in anaerobic microbial species mainly by the production of beta-l lactamase. Expand
...
1
2
3
4
5
...

References

SHOWING 1-3 OF 3 REFERENCES
THE INHIBITION OF THE BACTERIOSTATIC ACTION OF SULFONAMIDE DRUGS BY SUBSTANCES OF ANIMAL AND BACTERIAL ORIGIN
  • C. Macleod
  • Medicine
  • The Journal of experimental medicine
  • 1940
TLDR
Sulfonamide inhibitor has been demonstrated in extracts of fresh normal muscle, pancreas, and spleen of certain animals and in certain species of bacteria the inhibitor is found in the cells only and is not demonstrable in the culture medium. Expand
A wet-crushing mill for micro-organisms.