An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier

@article{Macfarlane1964AnEC,
  title={An Enzyme Cascade in the Blood Clotting Mechanism, and its Function as a Biochemical Amplifier},
  author={R. Macfarlane},
  journal={Nature},
  year={1964},
  volume={202},
  pages={498-499}
}
AFTER years of confusion, it seems that a relatively simple pattern is emerging from present theories of blood coagulation. Its recognition is assisted by the Roman numeral terminology of the International Committee on Blood Clotting Factors, which, by displacing a profusion of synonyms, allows the basis of factual agreement to be seen. Physiological clotting seems to be initiated by contact of the blood with the ‘foreign’ surfaces presented by many substances and tissues other than normal… Expand
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