An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.

@article{Harris2016AnES,
  title={An Engineered Switch in T Cell Receptor Specificity Leads to an Unusual but Functional Binding Geometry.},
  author={D. Harris and Nishant K. Singh and Qi Cai and Sheena N. Smith and C. V. Vander Kooi and E. Procko and D. Kranz and B. Baker},
  journal={Structure},
  year={2016},
  volume={24 7},
  pages={
          1142-1154
        }
}
Utilizing a diverse binding site, T cell receptors (TCRs) specifically recognize a composite ligand comprised of a foreign peptide and a major histocompatibility complex protein (MHC). To help understand the determinants of TCR specificity, we studied a parental and engineered receptor whose peptide specificity had been switched via molecular evolution. Altered specificity was associated with a significant change in TCR-binding geometry, but this did not impact the ability of the TCR to signal… Expand
15 Citations
Improving T Cell Receptor On-Target Specificity via Structure-Guided Design.
T-cell Receptors Engineered De Novo for Peptide Specificity Can Mediate Optimal T-cell Activity without Self Cross-Reactivity
Subtle changes at the variable domain interface of the T-cell receptor can strongly increase affinity
A generalized framework for computational design and mutational scanning of T-cell receptor binding interfaces.
Structure-guided engineering of the affinity and specificity of CARs against Tn-glycopeptides
Predicting antigen specificity of single T cells based on TCR CDR3 regions
...
1
2
...

References

SHOWING 1-10 OF 29 REFERENCES
In vitro evolution of a T cell receptor with high affinity for peptide/MHC.
Computational Design of the Affinity and Specificity of a Therapeutic T Cell Receptor
How structural adaptability exists alongside HLA-A2 bias in the human αβ TCR repertoire
...
1
2
3
...