An Engineered Allele of afsQ1 Facilitates the Discovery and Investigation of Cryptic Natural Products.

New approaches to antimicrobial discovery are needed to address the growing threat of antibiotic resistance. The Streptomyces genus, a proven source of antibiotics, is recognized as having a large reservoir of untapped secondary metabolic genes, many of which are likely to produce uncharacterized compounds. However, most of these compounds are currently… CONTINUE READING