An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes

@article{Skrun2009AnEF,
  title={An Endoribonuclease Functionally Linked to Perinuclear mRNP Quality Control Associates with the Nuclear Pore Complexes},
  author={Michal Skru{\vz}n{\'y} and Claudia Schneider and Attila R{\'a}cz and Julan Weng and David Tollervey and Ed Hurt},
  journal={PLoS Biology},
  year={2009},
  volume={7},
  pages={761 - 773}
}
Nuclear mRNA export is a crucial step in eukaryotic gene expression, which is in yeast coupled to cotranscriptional messenger ribonucleoprotein particle (mRNP) assembly and surveillance. Several surveillance systems that monitor nuclear mRNP biogenesis and export have been described, but the mechanism by which the improper mRNPs are recognized and eliminated remains poorly understood. Here we report that the conserved PIN domain protein Swt1 is an RNA endonuclease that participates in quality… CONTINUE READING

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