An Endogenous Nanomineral Chaperones Luminal Antigen and Peptidoglycan to Intestinal Immune Cells

@inproceedings{Powell2015AnEN,
  title={An Endogenous Nanomineral Chaperones Luminal Antigen and Peptidoglycan to Intestinal Immune Cells},
  author={Jonathan J. S. Powell and Emma Thomas-McKay and Vinay Thoree and Jack R. Robertson and Rachel E. Hewitt and Jeremy N. Skepper and Andy P. Brown and Juan Carlos Hernandez-Garrido and Paul A. Midgley and Inmaculada Gomez-Morilla and Geoffrey W Grime and Karen J Kirkby and Neil A Mabbott and David S Donaldson and Ifor R Williams and Daniel Zavala R{\'i}os and Stephen E. Girardin and Carolin Haas and Sylvaine F. A. Bruggraber and Jon D Laman and Yakup Tanriver and Giovanna Lombardi and R. Lechler and Richard P H Thompson and Laetitia C. Pele},
  booktitle={Nature nanotechnology},
  year={2015}
}
In humans and other mammals it is known that calcium and phosphate ions are secreted from the distal small intestine into the lumen. However, why this secretion occurs is unclear. Here, we show that the process leads to the formation of amorphous magnesium-substituted calcium phosphate nanoparticles that trap soluble macromolecules, such as bacterial peptidoglycan and orally fed protein antigens, in the lumen and transport them to immune cells of the intestinal tissue. The macromolecule… CONTINUE READING
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  • S Kimura
  • Mucosal. Immunol
  • 2014

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