An Emerging Role of the Angiotensin Receptor Binding Protein ATRAP as a Possible Novel Player in the Pathophysiology of Visceral Obesity and Metabolic Disorders

@inproceedings{Wakui2019AnER,
  title={An Emerging Role of the Angiotensin Receptor Binding Protein ATRAP as a Possible Novel Player in the Pathophysiology of Visceral Obesity and Metabolic Disorders},
  author={Hiromichi Wakui and Kengo Azushima and Kohji Ohki and Kazushi Uneda and Ryu Kobayashi and Toru Suzuki and Kouichi Tamura},
  year={2019}
}
Abstract Angiotensin II type 1 receptor (AT1R) is a major player in the signal transduction of the renin-angiotensin system, and overactivation of this signaling contributes to the progression of visceral obesity and metabolic disorders. AT1R-associated protein (ATRAP) promotes AT1R internalization along with the suppression of overactivation of tissue AT1R signaling. Adipose tissues from patients and mice with metabolic disorders exhibit decreased expression of ATRAP, despite its abundant… CONTINUE READING