An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion

@inproceedings{Toret2014AnEC,
  title={An Elmo–Dock complex locally controls Rho GTPases and actin remodeling during cadherin-mediated adhesion},
  author={Christopher P Toret and Caitlin Collins and W. James Nelson},
  booktitle={The Journal of cell biology},
  year={2014}
}
Cell-cell contact formation is a dynamic process requiring the coordination of cadherin-based cell-cell adhesion and integrin-based cell migration. A genome-wide RNA interference screen for proteins required specifically for cadherin-dependent cell-cell adhesion identified an Elmo-Dock complex. This was unexpected as Elmo-Dock complexes act downstream of integrin signaling as Rac guanine-nucleotide exchange factors. In this paper, we show that Elmo2 recruits Dock1 to initial cell-cell contacts… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 1 time over the past 90 days. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 12 extracted citations

Similar Papers

Loading similar papers…