An Efficient Nonviral Method to Generate Integration‐Free Human‐Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells

@article{Okita2013AnEN,
  title={An Efficient Nonviral Method to Generate Integration‐Free Human‐Induced Pluripotent Stem Cells from Cord Blood and Peripheral Blood Cells},
  author={Keisuke Okita and Tatsuya Yamakawa and Yasuko Matsumura and Yoshiko Sato and Naoki Amano and Akira Watanabe and Naoki Goshima and Shinya Yamanaka},
  journal={STEM CELLS},
  year={2013},
  volume={31}
}
The generation of induced pluripotent stem cells (iPSCs) provides the opportunity to use patient‐specific somatic cells, which are a valuable source for disease modeling and drug discovery. To promote research involving these cells, it is important to make iPSCs from easily accessible and less invasive tissues, like blood. We have recently reported the efficient generation of human iPSCs from adult fibroblasts using a combination of plasmids encoding OCT3/4, SOX2, KLF4, L‐MYC, LIN28, and shRNA… 

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