An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice

@inproceedings{Barth2012AnER,
  title={An Early Reduction in Treg Cells Correlates with Enhanced Local Inflammation in Cutaneous Leishmaniasis in CCR6-Deficient Mice},
  author={Thomas F. E. Barth and Dominic Schmidt and Catherine Botteron and Trang T.-B. Nguyen and Uwe Ritter and Daniela N M{\"a}nnel and Anja Lechner},
  booktitle={PloS one},
  year={2012}
}
Resistance to Leishmania major infection is dependent on the development of a cell-mediated Th1 immune response in resistant C57BL/6 mice whereas Th2-prone BALB/c mice develop non-healing lesions after infection. The chemokine receptor CCR6 is shared by anti-inflammatory regulatory T cells and pro-inflammatory Th17 cells. In a recent study we showed that C57BL/6 mice deficient in CCR6 exhibited enhanced footpad swelling and impaired T helper cell migration indicated by reduced recruitment of… CONTINUE READING

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