An ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival.

@article{Zhang2013AnEO,
  title={An ERBB3/ERBB2 oncogenic unit plays a key role in NRG1 signaling and melanoma cell growth and survival.},
  author={Keman Zhang and Poki Wong and Jiaqi Duan and Barbara Jacobs and Ernest C. Borden and Barbara Bedogni},
  journal={Pigment cell & melanoma research},
  year={2013},
  volume={26 3},
  pages={408-14}
}
We recently identified neuregulin-1 (NRG1) as a novel target of Notch1 required in Notch-dependent melanoma growth. ERBB3 and ERBB4, tyrosine kinase receptors specifically activated by NRG1, have been shown to be either elevated in melanoma cell lines and tumors or to be mutated in 20% of melanomas, respectively. While these data support key roles of NRG1 and its receptors in the pathogenesis of melanoma, whether ERBB3 and ERBB4 display redundant or exclusive functions is not known. Here, we… CONTINUE READING