An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.

@article{Manji2011AnEM,
  title={An ENU-induced mutation of Cdh23 causes congenital hearing loss, but no vestibular dysfunction, in mice.},
  author={Shehnaaz S M Manji and Kerry A Miller and Louise H. Williams and Lotte Andreasen and Maria Siboe and Elizabeth Rose and Melanie Bahlo and Michael J. Kuiper and Hans-Henrik M. Dahl},
  journal={The American journal of pathology},
  year={2011},
  volume={179 2},
  pages={
          903-14
        }
}
Mutations in the human cadherin 23 (CDH23) gene cause deafness, neurosensory, autosomal recessive 12 (DFNB12) nonsyndromic hearing loss or Usher syndrome, type 1D (characterized by hearing impairment, vestibular dysfunction, and visual impairment). Reported waltzer mouse strains each harbor a Cdh23-null mutation and present with hearing loss and vestibular dysfunction. Two additional Cdh23 mouse mutants, salsa and erlong, each carry a homozygous Cdh23 missense mutation and have progressive… CONTINUE READING

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