An ELISA-based high throughput protein truncation test for inherited breast cancer

@inproceedings{Lim2010AnEH,
  title={An ELISA-based high throughput protein truncation test for inherited breast cancer},
  author={Mark J. Lim and Gabriel J Foster and Sadanand Gite and Heather P Ostendorff and Steven A Narod and Kenneth J. Rothschild},
  booktitle={Breast Cancer Research},
  year={2010}
}
Breast cancer is the most diagnosed and second leading cause of cancer deaths in the U.S. female population. An estimated 5 to 10 percent of all breast cancers are inherited, caused by mutations in the breast cancer susceptibility genes (BRCA1/2). As many as 90% of all mutations are nonsense mutations, causing a truncated polypeptide product. A popular and low cost method of mutation detection has been the protein truncation test (PTT), where target regions of BRCA1/2 are PCR amplified… CONTINUE READING

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