An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.

@article{Goi2000AnER,
  title={An EGF receptor/Ral-GTPase signaling cascade regulates c-Src activity and substrate specificity.},
  author={Takanori Goi and Michail V. Shipitsin and Zifan Lu and David A. Foster and Stephan Klinz and Larry A. Feig},
  journal={The EMBO journal},
  year={2000},
  volume={19 4},
  pages={623-30}
}
c-Src is a membrane-associated tyrosine kinase that can be activated by many types of extracellular signals, and can regulate the function of a variety of cellular protein substrates. We demonstrate that epidermal growth factor (EGF) and beta-adrenergic receptors activate c-Src by different mechanisms leading to the phosphorylation of distinct sets of c-Src substrates. In particular, we found that EGF receptors, but not beta(2)-adrenergic receptors, activated c-Src by a Ral-GTPase-dependent… CONTINUE READING

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Stat3 activation is required for cellular Immunoprecipitations

  • J. F. Bromberg, C. M. Horvath, D. Besser, W. W. Lathem, J. E. Darnell, Jr.
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