An Aza resveratrol–chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress

@inproceedings{You2018AnAR,
  title={An Aza resveratrol–chalcone derivative 6b protects mice against diabetic cardiomyopathy by alleviating inflammation and oxidative stress},
  author={Shengban You and Jianchang Qian and Chuchu Sun and Hailing Zhang and Shiju Ye and Taiwei Chen and Zheng Xu and Jingying Wang and Wei-jian Huang and Guang Liang},
  booktitle={Journal of cellular and molecular medicine},
  year={2018}
}
Inflammation and oxidative stress play a crucial role in the development of diabetic cardiomyopathy (DCM). We previously had synthesized an Aza resveratrol-chalcone derivative 6b, of which effectively suppressing lipopolysaccharide (LPS)-induced inflammatory response in macrophages. This study aimed to investigate the potential protective effect of 6b on DCM and underlying mechanism. In H9c2 myocardial cells, 6b potently decreased high glucose (HG)-induced cell fibrosis, hypertrophy and… CONTINUE READING