An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel

@inproceedings{Xie2019AnAS,
  title={An Available Strategy for Nasal Brain Transport of Nanocomposite Based on PAMAM Dendrimers via In Situ Gel},
  author={Huichao Xie and Lingjun Li and Yue Jie Sun and Yuzhen Wang and Shuang Gao and Yuan Tian and Xuemei Ma and Chengcheng Guo and Fumin Bo and Li Zhang},
  booktitle={Nanomaterials},
  year={2019}
}
Polyamidoamine (PAMAM) dendrimers are efficient drug carriers. The presence of a physiological pathway for nasal brain transport provides a potential path for direct brain-targeted delivery of dendrimer nanocomposites. In this study, we synthesized PAMAM dendrimer composites with a nanoscale size; the particle size of PAE (Paeonol)/mPEG (the heterofunctional PEG polymer with a methoxy)-PAMAM G5.NHAc and mPEG-PAMAM G5.NH₂-FITC were 72.41 ± 11.58 nm and 96.51 ± 7.77 nm, and the zeta potential of… CONTINUE READING

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