An Automated Method to Quantify Microglia Morphology and Application to Monitor Activation State Longitudinally In Vivo


Microglia are specialized immune cells of the brain. Upon insult, microglia initiate a cascade of cellular responses including a characteristic change in cell morphology. To study the dynamics of microglia immune response in situ, we developed an automated image analysis method that enables the quantitative assessment of microglia activation state within… (More)
DOI: 10.1371/journal.pone.0031814


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