An Australian multicentre open label study of pergolide as an adjunct to levodopa in Parkinson's disease.


The efficacy and side effects of pergolide, a D(1) and D(2) dopamine agonist, were assessed in an open label study in 39 patients with long standing Parkinson's disease complicated by end of dose failure and/or dyskinesia. 27 patients completed 28 weeks of the study. The mean dose of pergolide was 2.26 mg/day (0.15-5.0mg/day). Levodopa was reduced by a mean… (More)