An Atypical Case of Atypical Hemolytic Uremic Syndrome: Predominant Gastrointestinal Involvement, Intact Renal Function, and C5b-9 Deposition in Colon and Skin

@article{Yao2015AnAC,
  title={An Atypical Case of Atypical Hemolytic Uremic Syndrome: Predominant Gastrointestinal Involvement, Intact Renal Function, and C5b-9 Deposition in Colon and Skin},
  author={Jocelyn De Yao and Robert B. Kaplan and Cynthia M. Magro},
  journal={Journal of hematology},
  year={2015},
  volume={4},
  pages={193-195}
}
Atypical hemolytic uremic syndrome (aHUS) is one of the prototypic thrombotic microangiopathies which arises from a genetically-based defect in the regulatory control of the alternate complement cascade. Although its cause is distinct, it shares a similar clinical presentation with thrombotic thrombocytopenic purpura with respect to its pattern of organ involvement, with most cases including the renal, central nervous, and gastrointestinal systems. Renal dysfunction in aHUS is generally… 
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Extra-renal manifestations of atypical hemolytic uremic syndrome

TLDR
Careful monitoring for extra-renal involvement is critical in patients with aHUS, as prompt evaluation and management may decrease the risk of high morbidity and mortality associated with a HUS.

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