An Atomic Model of the Interferon-β Enhanceosome

@article{Panne2007AnAM,
  title={An Atomic Model of the Interferon-β Enhanceosome},
  author={Daniel Panne and Tom Maniatis and Stephen C Harrison},
  journal={Cell},
  year={2007},
  volume={129},
  pages={1111-1123}
}
Transcriptional activation of the interferon-beta (IFN-beta) gene requires assembly of an enhanceosome containing ATF-2/c-Jun, IRF-3/IRF-7, and NFkappaB. These factors bind cooperatively to the IFN-beta enhancer and recruit coactivators and chromatin-remodeling proteins to the IFN-beta promoter. We describe here a crystal structure of the DNA-binding domains of IRF-3, IRF-7, and NFkappaB, bound to one half of the enhancer, and use a previously described structure of the remaining half to… CONTINUE READING
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