An Atlas of the Thioredoxin Fold Class Reveals the Complexity of Function-Enabling Adaptations

@inproceedings{Atkinson2009AnAO,
  title={An Atlas of the Thioredoxin Fold Class Reveals the Complexity of Function-Enabling Adaptations},
  author={Holly J. Atkinson and Patricia C. Babbitt},
  booktitle={PLoS Computational Biology},
  year={2009}
}
The group of proteins that contain a thioredoxin (Trx) fold is huge and diverse. Assessment of the variation in catalytic machinery of Trx fold proteins is essential in providing a foundation for understanding their functional diversity and predicting the function of the many uncharacterized members of the class. The proteins of the Trx fold class retain common features-including variations on a dithiol CxxC active site motif-that lead to delivery of function. We use protein similarity networks… CONTINUE READING