An Assessment of the Role of DNA Adenine Methyltransferase on Gene Expression Regulation in E coli

@article{Seshasayee2007AnAO,
  title={An Assessment of the Role of DNA Adenine Methyltransferase on Gene Expression Regulation in E coli},
  author={Aswin Seshasayee},
  journal={PLoS ONE},
  year={2007},
  volume={2},
  pages={183 - 192}
}
N6-Adenine methylation is an important epigenetic signal, which regulates various processes, such as DNA replication and repair and transcription. In gamma-proteobacteria, Dam is a stand-alone enzyme that methylates GATC sites, which are non-randomly distributed in the genome. Some of these overlap with transcription factor binding sites. This work describes a global computational analysis of a published Dam knockout microarray alongside other publicly available data to throw insights into the… CONTINUE READING