An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins.

@article{Cary2015AnAF,
  title={An Aspergillus flavus secondary metabolic gene cluster containing a hybrid PKS-NRPS is necessary for synthesis of the 2-pyridones, leporins.},
  author={J. Cary and V. Uka and Z. Han and Dieter Buyst and P. Y. Harris-Coward and K. Ehrlich and Q. Wei and D. Bhatnagar and P. Dowd and Stacey L Martens and A. Calvo and J. Martins and L. Vanhaecke and T. Coenye and S. de Saeger and J. D. di Mavungu},
  journal={Fungal genetics and biology : FG & B},
  year={2015},
  volume={81},
  pages={
          88-97
        }
}
  • J. Cary, V. Uka, +13 authors J. D. di Mavungu
  • Published 2015
  • Biology, Medicine
  • Fungal genetics and biology : FG & B
  • The genome of the filamentous fungus, Aspergillus flavus, has been shown to harbor as many as 56 putative secondary metabolic gene clusters including the one responsible for production of the toxic and carcinogenic, polyketide synthase (PKS)-derived aflatoxins. Except for the production of aflatoxins, cyclopiazonic acid and several other metabolites the capability for metabolite production of most of these putative clusters is unknown. We investigated the regulation of expression of the PKS-non… CONTINUE READING
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    References

    SHOWING 1-10 OF 46 REFERENCES