An Animal Model of Varicella Virus Infection

  title={An Animal Model of Varicella Virus Infection},
  author={T. White and D. Gilden and R. Mahalingam},
  journal={Brain Pathology},
  • T. White, D. Gilden, R. Mahalingam
  • Published 2001
  • Biology, Medicine
  • Brain Pathology
  • Varicella‐zoster virus (VZV) causes chickenpox in children; establishes latency in cranial nerve, dorsal root, and autonomic ganglia; and reactivates decades later to produce zoster. VZV produces disease only in humans. Although attempts to produce disease and study VZV latency in experimentally infected animals have resulted in virus in trigeminal or dorsal root ganglia, no clinical signs of infection or reactivation developed. In contrast, simian varicella virus (SVV) produces a naturally… CONTINUE READING
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