An Analytical Solution to the Kinetics of Breakable Filament Assembly

@article{Knowles2009AnAS,
  title={An Analytical Solution to the Kinetics of Breakable Filament Assembly},
  author={Tuomas P. J. Knowles and Christopher A. Waudby and Glyn L. Devlin and Samuel I. A. Cohen and Adriano Aguzzi and Michele Vendruscolo and Eugene M. Terentjev and Mark E. Welland and Christopher M. Dobson},
  journal={Science},
  year={2009},
  volume={326},
  pages={1533 - 1537}
}
Dissecting Amyloid Formation Amyloid fibrils are associated with clinical disorders ranging from Alzheimer's disease to type II diabetes. Their self-assembly can be described by a master equation that takes into account nucleation-dependent polymerization and fragmentation. Knowles et al. (p. 1533) now present an analytical solution to the master equation, which shows that amyloid growth kinetics is often limited by the fragmentation rate rather than by the rate of primary nucleation. In… Expand
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