An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety

@article{Bailey2014AnAO,
  title={An Analysis of the Use of Animal Models in Predicting Human Toxicology and Drug Safety},
  author={Jarrod Bailey and Michelle Thew and Michael Balls},
  journal={Alternatives to Laboratory Animals},
  year={2014},
  volume={42},
  pages={181 - 199}
}
Animal use continues to be central to preclinical drug development, in spite of a lack of its demonstrable validity. The current nadir of new drug approvals and the drying-up of pipelines may be a direct consequence of this. To estimate the evidential weight given by animal data to the probability that a new drug may be toxic to humans, we have calculated Likelihood Ratios (LRs) for an extensive data set of 2,366 drugs, for which both animal and human data are available, including tissue-level… 
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