An Analysis of Glycolytic Enzymes in the Cellular Response to Metal Toxicity
@inproceedings{Shanmuganathan2009AnAO, title={An Analysis of Glycolytic Enzymes in the Cellular Response to Metal Toxicity}, author={Anupama Shanmuganathan}, year={2009} }
Metal toxicity is implicated in neurotoxicity, nephrotoxicity, aging and cancer. Protein oxidation resulting from oxidative stress is now known to be involved in metal toxicity. However, proteomic responses to metal induced oxidative stress have not been characterized. By using the yeast as a model, we characterized these changes occurring in response to sub-lethal doses of metals. Several proteins involved in protein synthesis, ribosome assembly decreased while antioxidant defenses, proteins…
One Citation
Analysis of cellular responses to heavy metal-induced stress in Saccharomyces cerevisiae
- Biology
- 2014
A cytometric methodology is developed to assess the autophagic flow, that is less labor-intensive and more dynamic than the traditional Western blot-based method, and is able to decipher the factors of cell fate decision with heavy metal-induced oxidative stress in S. cerevisiae.
References
SHOWING 1-10 OF 254 REFERENCES
Copper‐induced oxidative stress in Saccharomyces cerevisiae targets enzymes of the glycolytic pathway
- BiologyFEBS letters
- 2004
Carbonylation of glycolytic proteins is a key response to drug-induced oxidative stress and apoptosis
- Biology, ChemistryCell Death and Differentiation
- 2004
It is demonstrated that protein carbonylation can be rapidly induced through cytotoxic drug treatment and may specifically inhibit the glycolytic pathway, which has severe implications for cell function.
Role of the glutathione/glutaredoxin and thioredoxin systems in yeast growth and response to stress conditions
- BiologyMolecular microbiology
- 2001
This review describes recent findings in the lower eukaryote Saccharomyces cerevisiae that are leading to a better understanding of their role in redox homeostasis in eUKaryotic cell metabolism.
Metal toxicity in yeasts and the role of oxidative stress.
- BiologyAdvances in applied microbiology
- 2001
Protein S-thiolation targets glycolysis and protein synthesis in response to oxidative stress in the yeast Saccharomyces cerevisiae.
- BiologyThe Biochemical journal
- 2003
Protein S-thiolation appears to serve an adaptive function during exposure to an oxidative stress by reprogramming metabolism and protecting protein synthesis against irreversible oxidation, and is proposed to result in glucose equivalents entering the pentose phosphate pathway for the generation of NADPH.
Mitochondrial Hsp60, Resistance to Oxidative Stress, and the Labile Iron Pool Are Closely Connected in Saccharomyces cerevisiae *
- BiologyThe Journal of Biological Chemistry
- 2002
The results indicate that the role of Hsp60 in oxidative-stress defense is explained by protection of several Fe/S proteins, which prevent the release of iron ions and thereby avert further damage.
The role of glutathione in copper metabolism and toxicity.
- BiologyThe Journal of biological chemistry
- 1989
Hydrogen peroxide-induced carbonylation of key metabolic enzymes in Saccharomyces cerevisiae: the involvement of the oxidative stress response regulators Yap1 and Skn7.
- Biology, ChemistryFree radical biology & medicine
- 2002
Cadmium-inducible Expression of the Yeast GSH1 Gene Requires a Functional Sulfur-Amino Acid Regulatory Network*
- BiologyThe Journal of Biological Chemistry
- 2000
Evidence is presented that the transcription factors involved in controlling the network of sulfur amino acid metabolism genes are also responsible for regulating GSH1 expression in response to cadmium.
Oxidative mechanisms in the toxicity of metal ions.
- Chemistry, BiologyFree radical biology & medicine
- 1995