An Analysis of Genetic Diversity and Inbreeding in Wuchereria bancrofti: Implications for the Spread and Detection of Drug Resistance

@article{Churcher2008AnAO,
  title={An Analysis of Genetic Diversity and Inbreeding in Wuchereria bancrofti: Implications for the Spread and Detection of Drug Resistance},
  author={Thomas S. Churcher and Anne E. Schwab and Roger K. Prichard and Mar{\'i}a-Gloria Bas{\'a}{\~n}ez},
  journal={PLoS Neglected Tropical Diseases},
  year={2008},
  volume={2},
  pages={313 - 321}
}
Estimates of genetic diversity in helminth infections of humans often have to rely on genotyping (immature) parasite transmission stages instead of adult worms. Here we analyse the results of one such study investigating a single polymorphic locus (a change at position 200 of the beta-tubulin gene) in microfilariae of the lymphatic filarial parasite Wuchereria bancrofti. The presence of this genetic change has been implicated in benzimidazole resistance in parasitic nematodes of farmed… CONTINUE READING

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