An Analysis by Synthesis Method that Allows Accurate Spatial Modeling of Thickness of Cortical Bone from Clinical QCT

  title={An Analysis by Synthesis Method that Allows Accurate Spatial Modeling of Thickness of Cortical Bone from Clinical QCT},
  author={Stefan Reinhold and T. Damm and S. B{\"u}sse and S. Gorb and C. Gl{\"u}er and R. Koch},
Osteoporosis is a skeletal disorder that leads to increased fracture risk due to decreased strength of cortical and trabecular bone. Even with state-of-the-art non-invasive assessment methods there is still a high underdiagnosis rate. Quantitative computed tomography (QCT) permits the selective analysis of cortical bone, however the low spatial resolution of clinical QCT leads to an overestimation of the thickness of cortical bone (this http URL) and bone strength. We propose a novel, model… Expand

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