An Altered aroA Gene Product Confers Resistance to the Herbicide Glyphosate.

@article{Comai1983AnAA,
  title={An Altered aroA Gene Product Confers Resistance to the Herbicide Glyphosate.},
  author={Lucio Comai and L C Sen and David M. Stalker},
  journal={Science},
  year={1983},
  volume={221 4608},
  pages={
          370-1
        }
}
The hypothesis that the herbicide glyphosate (N-phosphonomethylglycine) acts on plants and microorganisms by inhibiting synthesis of 5-enolpyruvyl-3-phosphoshikimate, a precursor to aromatic amino acids, was tested. Salmonella typhimurium was treated with ethyl methanesulfonate, and mutants mapping at the aroA locus, which encodes 5-enolpyruvyl-3-phosphoshikimate synthetase, were isolated by selection for glyphosate resistance. One of the mutants results in the synthesis of a 5-enolpyruvyl-3… CONTINUE READING

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