An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor

Abstract

The mechanism by which the epidermal growth factor receptor (EGFR) is activated upon dimerization has eluded definition. We find that the EGFR kinase domain can be activated by increasing its local concentration or by mutating a leucine (L834R) in the activation loop, the phosphorylation of which is not required for activation. This suggests that the kinase… (More)
DOI: 10.1016/j.cell.2006.05.013

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@article{Zhang2006AnAM, title={An Allosteric Mechanism for Activation of the Kinase Domain of Epidermal Growth Factor Receptor}, author={Xuewu Zhang and Jodi M. Gureasko and Kui Shen and Philip A. Cole and John Kuriyan}, journal={Cell}, year={2006}, volume={125}, pages={1137-1149} }