An Allergic Basis for Abdominal Pain.

@article{Rothenberg2021AnAB,
  title={An Allergic Basis for Abdominal Pain.},
  author={Marc E. Rothenberg},
  journal={The New England journal of medicine},
  year={2021},
  volume={384 22},
  pages={
          2156-2158
        }
}
  • M. Rothenberg
  • Published 3 June 2021
  • Medicine
  • The New England journal of medicine
Gastrointestinal symptoms are common in children and adults and often include abdominal pain after eating. Millions of people have chronic symptoms that have been labeled as functional gastrointestinal pain or irritable bowel syndrome (IBS) with no identifiable cause. This situation is frustrating for patients and their health care providers, since few effective treatments are available and those that are available do not provide satisfactory relief for many patients. Moreover, clinicians often… Expand

Figures from this paper

References

SHOWING 1-5 OF 5 REFERENCES
Local immune response to food antigens drives meal-induced abdominal pain
TLDR
It is shown that a bacterial infection and bacterial toxins can trigger an immune response that leads to the production of dietary-antigen-specific IgE antibodies in mice, which are limited to the intestine. Expand
Mast cell-dependent excitation of visceral-nociceptive sensory neurons in irritable bowel syndrome.
TLDR
Mucosal mast cell mediators from IBS patients excite rat nociceptive visceral sensory nerves in vitro, providing new insights into the mechanism underlying visceral hypersensitivity in IBS. Expand
Mechanisms of gastrointestinal allergic disorders.
TLDR
The latest findings on the molecular and cellular mechanisms that govern GI allergic diseases and how these findings have set the stage for emerging preventative and treatment strategies are discussed are discussed. Expand
Histamine Receptor H1-Mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome.
TLDR
Ebastine, an antagonist of HRH1, reduced visceral hypersensitivity, symptoms, and abdominal pain in patients with IBS and inhibitors of this pathway might be developed as a new treatment approach for IBS. Expand
Mast cells as sources of cytokines, chemokines, and growth factors
TLDR
The evidence indicating which cytokines and growth factors can be produced by various populations of rodent and human mast cells in response to particular immune or non‐immune stimuli is summarized, and the proven or potential roles of such mast cell products in health and disease are commented on. Expand