An Aggressive Temporal Bone Sdhc Paraganglioma Associated with Increased Hif-2α Signaling.


OBJECTIVE To describe a patient with a germline succinate dehydrogenase (SDHC) gene mutation presenting with primary hyperparathyroidism and a large catecholamine-producing temporal bone paraganglioma (PGL). METHODS Evaluation of a SDHC mutation-positive PGL tumor biology using staining for tyrosine hydroxylase (TH), hypoxia-inducible factors 1α (HIF-1… (More)
DOI: 10.4158/EP15889.OR


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