An Agglutinable Factor in Human Blood Recognized by Immune Sera for Rhesus Blood

@article{Landsteiner1940AnAF,
  title={An Agglutinable Factor in Human Blood Recognized by Immune Sera for Rhesus Blood},
  author={Karl Landsteiner and Alexander S. Wiener},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  year={1940},
  volume={43},
  pages={223 - 223}
}
  • K. Landsteiner, A. S. Wiener
  • Published 1 January 1940
  • Medicine, Biology
  • Proceedings of the Society for Experimental Biology and Medicine
The capacity possessed by some rabbit immune sera produced with blood of Rhesus monkeys, of reacting with human bloods that contain the agglutinogen M has been reported previously. 1 , 2 Subsequently it has been found that another individual property of human blood (which may be designated as Rh) can be detected by certain of these sera. Upon exhaustion of such a serum with selected bloods, for instance OM, the absorbed serum still agglutinated the majority (39 out of 45) of other human bloods… 
RHESUS FACTOR ISO‐IMMUNIZATION AND HAEMOLYTIC DISEASE OF THE NEWBORN *
TLDR
The obstetrician should be concerned in particular with this subject because certain complications which occur in obstetric patients are directly associated with incompatibilities of the rhesus blood-groups.
Hemolytic Transfusion Reactions. I. Diagnosis, with Special Reference to the Method of Differential Agglutination
TLDR
The property detected by the anti-rhesus serum and the irregular isoagglutinin has been designated as agglutinogen Rh by Landsteiner and Wiener, to indicate the manner in which it was discovered.
Blood group serology
TLDR
A series of tests reported by Karl Landsteiner in 1900 led to the discovery of the ABO blood groups and the development of routine blood grouping procedures, and ABO remains the most significant for transfusion practice.
The mosaic structure of red blood cell agglutinogens.
TLDR
It is now known that red cells are characterized by multiple rather than by single agglutinogens, at least one of which is species specific in that all members of a species appear to share it, and it is with these type specific agglutanogens, the blood group antigens, that the authors are primarily concerned.
THE MOSAIC STRUCTURE OF RED BLOOD CELL AGGLUTINOGENS
TLDR
It is now known that red cells are characterized by multiple rather than by single agglutinogens, at least one of which is species specific in that all members of a species appear to share it, and it is with these type specific agglutanogens, the blood group antigens, that the authors are primarily concerned.
Human Blood Groups
TLDR
The blood group of a person is dependent upon the presence in his erythrocytes of specific antigens, most easily demonstrated by agglutination methods, which may or may not be found naturally in human sera.
THE PASSIVE IMMUNITY OF THE YOUNG MAMMAL
TLDR
An important part of the resistance to disease with which an adult mammal is equipped is due to the production of circulating antibodies, molecules of soluble protein adapted to react specifically with foreign substances that have got into the system and induced their formation.
The self-marker concept as applied to the Rh blood group system.
  • K. Mayeda
  • Biology, Medicine
    American journal of human genetics
  • 1962
TLDR
A commonly ascribed reason for the failure of Rh negative women to produce antibodies against the Rh antigen of their Rh positive fetuses is the impermeability of the placental membrane to the fetal erythrocytes.
Five monoclonal antibodies against glycophorin A of human erythrocyte recognize glycoprotein of bovine erythrocyte.
TLDR
It was confirmed that these five MAbs recognized antigen epitope of glycosylation free amino acid portion but not glycosYLation portion of GPA of erythrocyte membrane as well as other components of bovine by enzyme treatment and monosaccharide competitive inhibition assay.
The importance of rhesus status
The history of haemolytic disease of the newborn, caused by incompatibility between the fetus and mother for the rhesus D (RhD) antigen, has been called one of the most brilliant successes achieved
...
...

References

SHOWING 1-2 OF 2 REFERENCES
The M Agglutinogen of Rhesus Monkeys
TLDR
Erythrocytes from rhesus monkeys were agglutinated by 18 of 58 rabbit immune sera from which 102 specific M typing fluids have been prepared, and two types of M-agglutinins were demonstrated.
On the Presence of M Agglutinogens in the Blood of Monkeys
TLDR
The explanation of the apparent discrepancies concerning the blood of lower monkeys has now been found in the fact that various anti-M immune sera are not identical in their reactions.