An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers

@inproceedings{Braeckel2011AnAP,
  title={An Adjuvanted Polyprotein HIV-1 Vaccine Induces Polyfunctional Cross-Reactive CD4+ T Cell Responses in Seronegative Volunteers},
  author={Eva Van Braeckel and Patricia Bourguignon and Marguerite Koutsoukos and Fr{\'e}d{\'e}ric Cl{\'e}ment and Michel H. Janssens and Isabelle Carletti and A-L. Collard and M A Demoiti{\'e} and G. S. Voss and Geert G. Leroux-Roels and Lisa McNally},
  booktitle={Clinical infectious diseases : an official publication of the Infectious Diseases Society of America},
  year={2011}
}
BACKGROUND This phase I/II partially blinded, randomized, dose-ranging study assessed the safety and immunogenicity of a novel human immunodeficiency virus type 1 (HIV-1) vaccine candidate consisting of a recombinant fusion protein (F4) containing 4 HIV-1 clade B antigens (Gag p24, Pol reverse transcriptase, Nef, and Gag p17) adjuvanted with AS01 in HIV-seronegative volunteers. Methods. Two doses of the recombinant F4 protein (10, 30, or 90 μg/dose), adjuvanted with AS01 or reconstituted with… CONTINUE READING

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