An Adaptive Grid Non-Parametric Approach to Pharmacokinetic and Dynamic (PK/PD) Population Models

@inproceedings{Leary2001AnAG,
  title={An Adaptive Grid Non-Parametric Approach to Pharmacokinetic and Dynamic (PK/PD) Population Models},
  author={R. Leary and Roger W. Jelliffe and A. Schumitzky and M. Van Guilder},
  booktitle={CBMS},
  year={2001}
}
Our NPEM software for non-parametric PK/PD population modeling employs the classical EM optimization algorithm to compute a maximum likelihood density on a fixed large multidimensional grid. The resulting support points and probabilities define a discrete distribution that approximates the maximum likelihood estimate of the true density, where the quality of the approximation is determined by the fineness of the grid. In order to achieve good resolution, a large number of grid points must be… CONTINUE READING
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