An Adaptive Gpc Approach to Low-flow Anaesthesia

  title={An Adaptive Gpc Approach to Low-flow Anaesthesia},
  author={Daniel Coca and Stephen A. Billings},
An adaptive method is developed to control the end-tidal isoflurane concentration using a low-flow method. The isoflurane concentration is calculated based on measurements of the end-tidal isoflurane concentration and mean arterial pressure (MAP) using a modelbased multivariable GPC algorithm. The control design allows explicit handling of input and output constrains, accommodates model uncertainty and takes into account possible MAP disturbances caused by surgical stimulation and blood loss… CONTINUE READING