An Ad/MVA vectored Theileria parva antigen induces schizont-specific CD8+ central memory T cells and confers partial protection against a lethal challenge

@inproceedings{Svitek2018AnAV,
  title={An Ad/MVA vectored Theileria parva antigen induces schizont-specific CD8+ central memory T cells and confers partial protection against a lethal challenge},
  author={Nicholas Svitek and Rosemary M Saya and Elias Awino and Stephen Ngao Munyao and Robert Mugambi Muriuki and Thomas M. Njoroge and Roger Pelle and Nicholas N. Ndiwa and Jane Poole and Sarah C Gilbert and Vishvanath M. Nene and Lucilla Steinaa},
  booktitle={npj Vaccines},
  year={2018}
}
The parasite Theileria parva is the causative agent of East Coast fever (ECF), one of the most serious cattle diseases in sub-Saharan Africa, and directly impacts smallholder farmers’ livelihoods. There is an efficient live-parasite vaccine, but issues with transmission of vaccine strains, need of a cold chain, and antibiotics limit its utilization. This has fostered research towards subunit vaccination. Cytotoxic T lymphocytes (CTL) are crucial in combating the infection by lysing T. parva… CONTINUE READING

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