An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress

@article{West2017AnAN,
  title={An Actomyosin-Arf-GEF Negative Feedback Loop for Tissue Elongation under Stress},
  author={Junior J. West and Teresa Zulueta-Coarasa and Janna A. Maier and Donghoon M. Lee and Ashley E. E. Bruce and Rodrigo Fernandez-Gonzalez and Tony J.C. Harris},
  journal={Current Biology},
  year={2017},
  volume={27},
  pages={2260-2270.e5}
}
In response to a pulling force, a material can elongate, hold fast, or fracture. During animal development, multi-cellular contraction of one region often stretches neighboring tissue. Such local contraction occurs by induced actomyosin activity, but molecular mechanisms are unknown for regulating the physical properties of connected tissue for elongation under stress. We show that cytohesins, and their Arf small G protein guanine nucleotide exchange activity, are required for tissues to… CONTINUE READING
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