An Active Pulse Transmission Line Simulating Nerve Axon

@article{Nagumo1962AnAP,
  title={An Active Pulse Transmission Line Simulating Nerve Axon},
  author={Jin-ichi Nagumo and S. Arimoto and Shuji Yoshizawa},
  journal={Proceedings of the IRE},
  year={1962},
  volume={50},
  pages={2061-2070}
}
To electronically simulate an animal nerve axon, the authors made an active pulse transmission line using tunnel diodes. The equation of propagation for this line is the same as that for a simplified model of nerve membrane treated elsewhere. This line shapes the signal waveform during transmission, that is, there being a specific pulse-like waveform peculiar to this line, smaller signals are amplified, larger ones are attenuated, narrower ones are widened and those which are wider are shrunk… Expand
View on IEEE
doi.org
2,428 Citations
Highly Influential Citations
77
Background Citations
287
Methods Citations
445
Results Citations
10

2,428 Citations

Citation Type

Citation Type

An electronic circuit model of nerve axon for signal transmission
An electronic circuit model of signal propagation in the nerve axon that is based on the neuristor proposed by H.D. Crane (1960) is described. This circuit is a cascade of identical active network… Expand
Modeling and simulating the nerve axon as a thin-film microstrip
Since Hodgkin and Huxley described the nerve axon as a cable (H–H model), many efforts have been made to find more approximated transmission line models representing the nerve axon. This paper… Expand
Autowave Processes, Nerve Pulse Propagation, and Heart Activity
The main property of nerve cells is their ability to conduct nerve pulses—electrical waves spreading along the nerve fiber. The conduction property is based on the fact that the elementary volume of… Expand
Spiking computation and stochastic amplification in a neuron-like semiconductor microstructure
We have demonstrated the proof of principle of a semiconductor neuron, which has dendrites, axon, and a soma and computes information encoded in electrical pulses in the same way as biological… Expand
Some properties of transmission lines composed of random networks
Abstract This paper discusses some properties of a nerve-axon-like transmission line made up from random networks of threshold elements. A random network contains a large number of threshold elements… Expand
On a stability property of double-pulse solutions in nerve axon equations
In nerve axon equations, when a double-pulse solution is stable, any small initial deviation decays exponentially up to a small spatial phase shift. In particular, if the separation of the two pulses… Expand
ns Pulsed Electric Field-Induced Action Potentials in the Circuital Model of an Axon
TLDR
The circuital model per surface unit of the plasma membrane of an axon was developed to implement the Hodgkin and Huxley equations, and by using a power electronics tool, easier integration of the cell modeling with the design and optimization of pulse generation systems can be gained. Expand
Noise induced amplification of sub-threshold pulses in multi-thread excitable semiconductor ‘neurons’
We report on the transmission of electrical pulses through a semiconductor structure which emulates biological neurons. The ‘neuron’ emits bursts of electrical spikes whose coherence we study as a… Expand
The spike generation zone of the ampullary electroreceptor
TLDR
A novel circuit design consisting of an operational amplifier, a tunnel diode and linear passive components is intended to model the spike generation zone at which the transformation of neural input from slow to fast format takes place, producing a stimulus-response characteristic which can be compared with those observed in vivo. Expand
An MMIC implementation of FitzHugh–Nagumo neurons using a resonant tunneling diode nonlinear transmission line
In this paper the electronic implementation of FitzHugh–Nagumo (F–N) neurons via monolithic microwave integrated circuits (MMIC) based upon a resonant tunneling diode (RTD) nonlinear transmission… Expand
...
1
2
3
4
5
...

References

SHOWING 1-8 OF 8 REFERENCES
Computation of impulse initiation and saltatory conduction in a myelinated nerve fiber.
A mathematical model of the electrical properties of a myelinated nerve fiber is given, consisting of the Hodgkin-Huxley ordinary differential equations to represent the membrane at the nodes of… Expand
Impulses and Physiological States in Theoretical Models of Nerve Membrane.
TLDR
Van der Pol's equation for a relaxation oscillator is generalized by the addition of terms to produce a pair of non-linear differential equations with either a stable singular point or a limit cycle, which qualitatively resembles Bonhoeffer's theoretical model for the iron wire model of nerve. Expand
Electronic Control of Some Active Bioelectric Membranes
Special purpose real-time analog computers are used to measure and control nerve membrane potential or current in a squid axon or a single frog node. Under current control, the membrane potential has… Expand
Thresholds and Plateaus in the Hodgkin-Huxley Nerve Equations
  • R. FitzHugh
  • Physics, Medicine
  • The Journal of general physiology
  • 1960
TLDR
Since the theoretical membrane conductance curves differ significantly from the experimental ones, further experimental analysis of ionic currents with tetraethylammonium is needed to decide whether the Hodgkin-Huxley model can be generalized to explain these experiments completely. Expand
A quantitative description of membrane current and its application to conduction and excitation in nerve
TLDR
This article concludes a series of papers concerned with the flow of electric current through the surface membrane of a giant nerve fibre by putting them into mathematical form and showing that they will account for conduction and excitation in quantitative terms. Expand
Automatic Computation of Nerve Excitation—Detailed Corrections and Additions
Automatic Computation of Nerve Excitation, Correction
Automatic Computation of Nerve Excitation