An Acid-Sensing Channel Sows Fear and Panic

@article{Maren2009AnAC,
  title={An Acid-Sensing Channel Sows Fear and Panic},
  author={Stephen Maren},
  journal={Cell},
  year={2009},
  volume={139},
  pages={867-869}
}
The amygdala is a brain region that coordinates fear responses to a variety of threats. Ziemann et al. (2009) now show that acid-sensing channels in the amygdala mediate fear responses that accompany inhalation of carbon dioxide, suggesting that aberrant chemosensation may underlie anxiety disorders associated with a fear of suffocation. 
View on Elsevier
deepblue.lib.umich.edu
11 Citations
Highly Influential Citations
1
Background Citations
5

11 Citations

Citation Type

Citation Type

Brain angiotensin AT1 receptors as specific regulators of cardiovascular reactivity to acute psychoemotional stress
  • D. Mayorov
  • Medicine
  • Clinical and experimental pharmacology & physiology
  • 2011
  • 23
NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice.
  • 2
Current perspectives on acid-sensing ion channels: new advances and therapeutic implications
  • 45
Pharmacology of ASIC channels
  • 16
Hypersensitivity to hypercapnia: Definition/(s)
  • 5
Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels.
  • 70
  • PDF
35% CO2 sensitivity in social anxiety disorder
  • 11
  • PDF
Emotional reactivity to a single inhalation of 35% carbon dioxide and its association with later symptoms of posttraumatic stress disorder and anxiety in soldiers deployed to Iraq.
  • 24
  • PDF
Ion Channels as Drug Targets in Central Nervous System Disorders
  • 67
  • PDF
The affective response to CO2 in healthy volunteers : an instance of a primal emotion
  • PDF
...
1
2
...

References

SHOWING 1-10 OF 19 REFERENCES
Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses
  • 78
  • PDF
Neurobiology of Pavlovian fear conditioning.
  • Stephen Maren
  • Psychology, Medicine
  • Annual review of neuroscience
  • 2001
  • 1,527
  • PDF
Serotonergic neurons as carbon dioxide sensors that maintain ph homeostasis
  • G. Richerson
  • Biology, Medicine
  • Nature Reviews Neuroscience
  • 2004
  • 462
False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis.
  • D. Klein
  • Psychology, Medicine
  • Archives of general psychiatry
  • 1993
  • 998
Emotion Circuits in the Brain
  • 4,712
A modern learning theory perspective on the etiology of panic disorder.
  • 878
  • PDF
The Acid-Activated Ion Channel ASIC Contributes to Synaptic Plasticity, Learning, and Memory
  • 543
Electrophysiological characteristics of amygdaloid central nucleus neurons in the awake rabbit
  • 70
BRAIN RES BULL
  • 373
J. Neurosci
  • J. Neurosci
  • 2008
...
1
2
...