An Acid-Sensing Channel Sows Fear and Panic

  title={An Acid-Sensing Channel Sows Fear and Panic},
  author={Stephen Maren},
Brain angiotensin AT1 receptors as specific regulators of cardiovascular reactivity to acute psychoemotional stress
  • D. Mayorov
  • Biology, Psychology
    Clinical and experimental pharmacology & physiology
  • 2011
1. Cardiovascular reactivity, an abrupt rise in blood pressure (BP) and heart rate in response to psychoemotional stress, is a risk factor for heart disease. Pharmacological and molecular genetic
NO in the dPAG modulates panic-like responses and ASIC1a expression in the prefrontal cortex and hippocampus in mice.
Current perspectives on acid-sensing ion channels: new advances and therapeutic implications
Acid-sensing ion channels emerge as new potential therapeutic targets in the management of psychiatric disorders, stroke, neurodegenerative diseases and pain.
Pharmacology of ASIC channels
A combination of genetic and pharmacologic approaches using the weakly selective inhibitor amiloride and more selective peptide toxins has revealed the implication of ASIC channels in an increasing number of physiological and pathophysiological processes, ranging from synaptic plasticity, learning, memory, fear, depression, seizure termination and neuronal degeneration to nociception and mechanosensation.
Hypersensitivity to hypercapnia: Definition/(s)
Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels.
35% CO2 sensitivity in social anxiety disorder
Neither the experiment nor the meta-analyses found evidence for a similarly exaggerated 35% CO2 sensitivity in SAD and PD, suggesting that the pathogenesis of SAD is different from PD, although patients with SAD may be slightly more sensitive than non-anxious controls.
Emotional reactivity to a single inhalation of 35% carbon dioxide and its association with later symptoms of posttraumatic stress disorder and anxiety in soldiers deployed to Iraq.
Soldiers' emotional reactivity to a 35% CO(2) challenge may serve as a vulnerability factor for increasing soldiers' risk for PTSD and general anxiety/stress symptoms in response to war-zone stressors.
Ion Channels as Drug Targets in Central Nervous System Disorders
This review is focusing on ion channels subtypes, which play a significant role in current drug discovery and development process, and new channels such as P2X1-P2X7, as well as TRPA1-TRPV1 have been discovered, giving premises for new types of analgesic drugs.
The affective response to CO2 in healthy volunteers : an instance of a primal emotion
The final author version and the galley proof are versions of the publication after peer review that features the final layout of the paper including the volume, issue and page numbers.


Restoring Acid-Sensing Ion Channel-1a in the Amygdala of Knock-Out Mice Rescues Fear Memory But Not Unconditioned Fear Responses
This work rescued context-dependent fear memory, but not the freezing deficit during training or the unconditioned fear response to predator odor, and illustrates a strategy for identifying discrete brain regions where specific genes contribute to complex behaviors.
Neurobiology of Pavlovian fear conditioning.
  • Stephen Maren
  • Biology, Psychology
    Annual review of neuroscience
  • 2001
Advances in neural circuits underlying fear conditioning have been mapped, synaptic plasticity in these circuits has been identified, and biochemical and genetic manipulations are beginning to unravel the molecular machinery responsible for the storage of fear memories.
Serotonergic neurons as carbon dioxide sensors that maintain ph homeostasis
Serotonergic neurons in the medulla have been shown to be sensors of carbon dioxide and pH, and this role in control of pH homeostasis could provide a neurobiological explanation for the link between changes in the serotonin system and sudden infant death syndrome (SIDS).
False suffocation alarms, spontaneous panics, and related conditions. An integrative hypothesis.
  • D. Klein
  • Psychology
    Archives of general psychiatry
  • 1993
The phenomena of panic during relaxation and sleep, late luteal phase dysphoric disorder, pregnancy, childbirth, pulmonary disease, separation anxiety, and treatment are used to test and illuminate the suffocation false alarm theory.
Emotion Circuits in the Brain
The field of neuroscience has, after a long period of looking the other way, again embraced emotion as an important research area. Much of the progress has come from studies of fear, and especially
A modern learning theory perspective on the etiology of panic disorder.
The authors propose that PD develops because exposure to panic attacks causes the conditioning of anxiety (and sometimes panic) to exteroceptive and interoceptive cues, which begins the individual's spiral into PD.
Electrophysiological characteristics of amygdaloid central nucleus neurons in the awake rabbit