An Achilles' heel for breast cancer?

Individuals harboring heterozygous mutations in the tumor suppressors BRCA1 or BRCA2 are at greatly increased risk of developing breast tumors through loss of heterozygosity. Indeed, mutations in BRCA1 or BRCA2 account for 80–90% of all hereditary breast cancer, and BRCA1 is strongly linked with ovarian cancer. Two recent papers published in Nature1,2 raise… CONTINUE READING