An ATRActive future for differentiation therapy in AML.

  title={An ATRActive future for differentiation therapy in AML.},
  author={Daniel Ezra Johnson and Robert L Redner},
  journal={Blood reviews},
  volume={29 4},
The success of all-trans retinoic acid (ATRA) therapy in acute promeylocytic leukemia (APL) has spawned numerous attempts to translate the paradigm of differentiation therapy to non-APL acute myelocytic leukemia (AML). However, the results of clinical trials have been overall disappointing. In this review we discuss the mechanism of retinoic acid signaling and the results of major clinical trials that have attempted to incorporate ATRA into AML regimens. We discuss recent evidence that indicate… CONTINUE READING

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