An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.

Abstract

We have analyzed how single-strand DNA gaps affect DNA replication in Xenopus egg extracts. DNA lesions generated by etoposide, a DNA topoisomerase II inhibitor, or by exonuclease treatment activate a DNA damage checkpoint that blocks initiation of plasmid and chromosomal DNA replication. The checkpoint is abrogated by caffeine and requires ATR, but not ATM… (More)

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Cite this paper

@article{Costanzo2003AnAA, title={An ATR- and Cdc7-dependent DNA damage checkpoint that inhibits initiation of DNA replication.}, author={Vincenzo Costanzo and David Z Shechter and Patrick J. Lupardus and Karlene A Cimprich and Max E. Gottesman and Jean Gautier}, journal={Molecular cell}, year={2003}, volume={11 1}, pages={203-13} }