An ARV1 homologue from a filarial nematode is functional in yeast

  title={An ARV1 homologue from a filarial nematode is functional in yeast},
  author={Harshini Herath and Yasanthi Illika Nilmini Silva Gunawardene and M. Pathiranage and Priyanka Wickramasinghe and P.G.T.S. Wickramatunge and Ranil Samantha Dassanayake},
  journal={Journal of Helminthology},
  pages={12 - 20}
Abstract The transmembrane protein, ARV1, plays a key role in intracellular sterol homeostasis by controlling sterol distribution and cellular uptake. To date, only the ARV1s from yeast and humans have been characterized to some extent. In this study, the ARV1 of an animal filarial parasite, Setaria digitata (SdARV1), was characterized; its cDNA was 761 bp and encoded a protein of 217 amino acids, with a predicted molecular weight of 25 kDa, containing a highly conserved ARV1 homology domain… 
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